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Border Collie Information
Hereditary Diseases in Border Collies - this is why we DNA test our breeding stock
Clear X Carrier = on average, 50% Clear, 50% Carriers
Clear X Affected = 100% Carriers
Carrier X Carrier = on average, 25% Clear, 50% Carriers, 25% Affected
Carrier X Affected = on average, 50% Affected, 50% Carriers
Affected X Affected = 100% Affected
- CEA/CH - Collie Eye Anomaly/Choroidal Hypoplasis Is not progressive in the usual sense. The essential feature, chroidal hypoplasia and coloboma, and congenital the abnormalities develop as the eye develop. These features are also stationary once development is complete around 1-12 weeks of life. Retinal detachments and/or aberrant vessel formation can be congenital or develop later, in general only in eyes with colobomas.
Clear X Carrier = on average, 50% Clear, 50% Carriers
Clear X Affected = 100% Carriers
Carrier X Carrier = on average, 25% Clear, 50% Carriers, 25% Affected
Carrier X Affected = on average, 50% Affected, 50% Carriers
Affected X Affected = 100% Affected
- NCL (CL) - Neuronal Ceroid Lipofuscino sis A late on set nerve degenerative disease like Batten disease in humans. Neuronal ceroil lipofuscino sis is a type of lysosmal storage disorder that results in accumulation of lysosmal staoage bodies in the cells of many tissues of the affected animal. This leads to progressive neurodegeneration (degeneration of brain and eye cells) and results in severe neurological impairment and early death.
- TNS - Trapped Neutrophil Syndeom A Hereditary disease where the bone marrow produces neutrophils (white blood cells) but is unable to effectively release them into the blood stream. Affected puppies have an impaired immune system and will eventually die from infections they cannot fight.
- Raine Syndrome Dental Canine dental hypomineralization or Raine Syndrome is a genetic disorder affecting the Border Collies. The disorder causes severe tooth wear resulting in pulpitis and requiring extraction of those teeth. Dental hypomineralization is a canine model for human Raine Syndrome. Dental examination of the affected dogs reveals significant wear.Lower incisor teeth can be worn close to the gingival margin. The enamel shows a light brown discoloration and appears dull. Some worn teeth can have a pulp exposure and pulpits as a result of the wear.
- Goniodysgenesis and Glaucome Goniodysgenesis is a condition cause by the abnormal development of the eye which can result in excessive pressure buildup, eventually causing permanent damage to the optic nerve. resulting in blindness. Goniodysgenesis also known as mesodermal dysgenesis, is an abnormality of the anterior chamber of the eye, and it has been associated with glaucoma and blindness. Most forms of glaucoma can be placed in two categories, primary and secondary. The term primary glaucoma is used to describe those types of glaucoma caused by an inherited physical or physiological trait that an animal has been predisposed to. (Secondary glaucoma is the term referred to when the disease is triggered by something other than genetics). Many dogs affected by glaucoma will become blind in the affected eye in the first year.